Overview

PGxAI InheritRisk

AI-powered carrier screening for reproductive planning and genetic risk assessment.

Overview

PGxAI InheritRisk is a comprehensive carrier screening test designed to detect pathogenic variants associated with inherited conditions. Using monogenic analysis and AI-powered interpretation, it helps individuals and families assess reproductive risk and make informed decisions

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Detects clinically significant variants in autosomal and X-linked conditions

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Reports carrier status with zygosity, inheritance pattern, and offspring risk

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Includes actionable insights for reproductive risk assessment and partner testing

Report Preview

Concise, One-Page Summary of Key Carrier Status Findings

Genes Covered

HBB

Carrier of Sickle Cell Trait

DMD

Carrier of Duchenne Muscular Dystrophy

CFTR

Carrier of Cystic Fibrosis

GBA

Carrier of Gaucher Disease

PAH

Carrier of Phenylketonuria

SMN1

Carrier of Spinal Muscular Atrophy

Use & Evidence

Who It’s For

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Couples planning pregnancy

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Fertility clinics and reproductive endocrinologists

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Prenatal and preimplantation genetic counseling programs

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General practitioners offering preventive care

Scientific Basis

PGxAI InheritRisk aligns with the latest guidelines from the American College of Medical Genetics and Genomics (ACMG), offering a comprehensive, population-neutral carrier screening approach. The test encompasses a broad panel of autosomal recessive and X-linked conditions, ensuring equitable evaluation across diverse populations. Carrier screening is recommended by both ACMG and the American College of Obstetricians and Gynecologists (ACOG) as an integral part of reproductive planning, even for individuals without a known family history of genetic disorders. Studies have demonstrated that expanded carrier screening can identify carriers for various conditions in approximately 24% of individuals tested, highlighting its significance in proactive healthcare decisions Hum Genet. 2019