Jul 18, 2025

Benchmarking large language models for replication of guideline-based PGx recommendations

Study evaluates leading LLMs on 599 CPIC‑aligned gene–drug–phenotype scenarios and introduces a domain‑adapted approach that improves clinical accuracy and speed.

news image

PGx testing can markedly improve treatment safety and efficacy, yet adoption in health systems remains slow. Our latest peer‑reviewed study—now published in The Pharmacogenomics Journal (Nature Portfolio)—benchmarks how well large language models (LLMs) reproduce guideline‑based pharmacogenomic (PGx) recommendations and outlines a practical path from static, one‑time advice to dynamic guidance updated in real time. Nature

Key findings

General‑purpose models often produced incomplete or unsafe outputs when asked for guideline‑conformant PGx recommendations.

Domain adaptation (including targeted fine‑tuning and structured prompting) substantially improves accuracy and reduces latency, making PGx‑specific LLMs more suitable for clinical decision support.

Why this matters LLMs purpose‑built for PGx can help close the gap between genetic results and bedside actionability—supporting safer, faster, and more consistent medication decisions across diverse patient populations.

Looking ahead We have already released a closed model, Deneb, capable of generating recommendations in real time. Comparative testing against the latest versions (o3, o3-pro, grok-4, claude-4, etc.) will be shared soon.

Success Stories
Serving Every Stakeholder in Healthcare
image
News
Jul 18, 2025
Benchmarking LLMs for Pharmacogenomic (PGx) Recommendations
image
News
July 04, 2025
AI & Multi-Omics in Pharmacogenomics: PGxAI’s New Review
image
Press Release
Jun 27, 2025
PGxAI Unveils Betelgeuse — New AI Model for Real-Time Clinical Outcome Analysis and Adaptive Recommendations
image
News
Jun 14, 2025
Upload Your Own Genetic Data: Instant Drug-Sensitivity Insights Now in All Base Models
image
News
Jun 1, 2025
Bruce Broussard, Former Humana CEO, Joins PGxAI as Advisor for Reimbursement Strategy
image
News
May 16, 2025
Drug-Drug Interaction Module—FDA-Label Powered, Terminal-Ready—Now Live in All Open Models
image
News
Apr 23, 2025
PGxAI Unveils AI-Driven Genetic Tool to Personalize GLP-1 Drugs Including Ozempic®
image
News
Apr 15, 2025
PGxAI Debuts Deneb, an AI Model Revolutionizing Drug Development for Biopharma
image
News
Mar 16, 2025
Automated Phenoconversion Arrives: Real-Time, Context-Aware Drug-Response Scoring in Every Base Model
image
News
Feb 28, 2025
PGxAI Debuts Vega, an AI Model Set to Disrupt Precision Medicine
image
Press Release
Dec 24, 2024
Revolutionizing Precision Medicine: PGxAI Raises $1.5 Million in Funding for AI-Powered Pharmacogenetics Platform
image
News
Dec 21, 2024
The Ventures Award: The World's Premier Stage for Startup Excellence
image
Press Release
Dec 19, 2024
PGxAI Launches Sirius, an AI‑Powered Pharmacogenetics Model
image
Press Release
Jun 25, 2024
IPA’s Subsidiary BioStrand and PGxAI Announce Strategic Collaboration